Ihe ngosi nri China Weihai
Die Young Die Trying - Ị chọrọ ịdị ndụ ebighị ebi? Bụrụ onye na-adịghị anwụ anwụ, nọrọ nwata, nwee ahụ ike. Akụkọ kacha ọhụrụ na sayensị nke ogologo ndụ.
Die Young Die Trying. Ederede. Lelee "Ihe ebube nke anwụghị anwụ" n'ịntanetị, ihe nkiri isiokwu anwụghị anwụ nke mbụ China. IndieBio lekwasịrị anya na bayoloji ma tinye ego n'ọtụtụ ego ụlọ ọrụ ndu. Science Longevity song, ma na-akpali nnọọ mmasị, mụtara ihe ọmụma. Jiri nnwale sayensị chọpụta ngwaahịa NMN adịgboroja. Bezos na ndị ọzọ billionaires itinye ego na mgbochi ịka nká ụlọ ọrụ Altos, cell reprogramming technology ga-esote uto ?. Mgbanwe ọbara, ọgwụ na mkpụrụ ndụ ihe nketa, ndị ọgaranya Silicon Valley chọrọ iji ego zụta ọnwụ. Ndị ọkà mmụta sayensị China achọpụtala ihe “mgbochi ịka nká” iji nyere ụmụ oke aka ịgbatị ndụ etiti ahụike site na 64.2%. Syros Pharmaceuticals genome regulatory mpaghara ọmụmụ. Ntugharị posts. Chọọ akụkọ. Otu. Ga-agụ Akụkọ. Edemede nso nso a. Debanye aha na blọgụ site na email. Ebe nchekwa. onye isi oche. Oke osimiri Oikawa.
Ị chọrọ ịdị ndụ ebighị ebi? Bụrụ onye na-adịghị anwụ anwụ, nọrọ nwata, nwee ahụ ike. Akụkọ kacha ọhụrụ na sayensị nke ogologo ndụ.
Mmemme IndieBio bụ akụkụ nke SOSV, ego azụmaahịa dabere na US nke na-ahụ maka itinye ego n'oge mmalite na ngalaba ndị a, ya bụ biotechnology (IndieBio), teknụzụ siri ike (HAX), ndị ahịa na-agafe agafe Asia na ụlọ ọrụ (MOX na Chinaaccelerator) , na blockchain (dlab). Emebere mmemme SOSV iji nye ndị na-emepụta ihe enyemaka 1: 1 siri ike sitere n'aka ndị teknụzụ na ndị nkuzi mmalite n'ụlọ ọrụ zuru oke iji wulite ngwaahịa ha na ịmalite ụlọ ọrụ ha.
Vidiyo egwu ọhụrụ: Egwu ogologo ndụ!#ogologo ndụ #science #sciencemusic #sciencesong #scicomm pic.twitter.com/k4MlULULJw.
https://mp.weixin.qq.com/s?__biz=Mzg3ODMxNjk3MA==&mid=2247501083&idx=1&sn=f5df69af58bfeb193e248059c100ea9c&chksm=cf1719def86090c8775d2010f5fc7dd1c7014c7033be31203bdcc4538fe70d800e0a6fcc99eb&scene=27#wechat_redirect.
Dabere na CB Insights, ụlọ ọrụ biotech Altos Labs (Altos) dechara mmụọ ozi gburugburu na Septemba 8 nke afọ a, yana ndị na-etinye ego gụnyere Bezos, Yuri Milner na nwunye ya Julia Milner. Dika nkwuputa nkwuputa nha nha nke etinyere na California na June, Altos akwalitela opekata mpe $270, gụnyere ụfọdụ billionaires teknụzụ na VC. Na mgbakwunye, ụlọ ọrụ ahụ na-ezube iguzobe ọtụtụ ụlọ ọrụ nyocha na mpaghara San Francisco Bay, San Diego, Cambridge, United Kingdom, Japan na ebe ndị ọzọ.
Nzukọ a mere ka e guzobe Altos. Dị ka ụlọ ọrụ biotechnology na-amalite, Altos tọrọ ntọala ka ọ nyochaa ka mmadụ si eme "anwụ anwụ". Na mgbakwunye na onye ijeri Russia Yuri Milner, ndị na-etinye ego nke ụlọ ọrụ ahụ bụkwa onye nchoputa Amazon Jeff Bezos.
Nke a abụghị nke mbụ Bezos na-etinye ego na egwu na-agbatị ndụ. Laa azụ na 2016, o tinyere ego na ụlọ ọrụ teknụzụ a na-akpọ Unity Biotechnology iji mụọ ka esi ebelata ịka nká. Dị ka CB Insights si kwuo, ụlọ ọrụ ahụ mezuru usoro ego nke usoro B na October 2016, na-ebuli mkpokọta $ 116 nde. Ndị na-etinye ego na-etinye ego n'ọkwa ego a gụnyere Bezos, onye nchoputa PayPal Peter Thiel, Fidelity Investments, BlackPine Private Equity Partners na ụlọ ọrụ ntinye ego 8 ndị ọzọ.
Na Mee 3, 2018, e depụtara Unity Biotechnology na NASDAQ na United States n'okpuru akara akara UBAX, yana nnukwu ego ahịa bụ nde $712. Ruo Disemba 8, 2021, isi ahịa ụlọ ọrụ ahụ bụ $108 nde. Otú ọ dị, n'August afọ gara aga, ụlọ ọrụ ahụ dara na usoro nke abụọ nke nyocha banyere ọgwụ mgbochi ịka nká UBX0101, na-eme ka uru ahịa ya daa site na 60% na ụlọ ọrụ ahụ na-adaba n'ọnọdụ nke layoffs na nhazigharị. Onye isi oche Anirvan Ghosh kwuru na nhazigharị ahụ ga-elekwasị anya na nyocha anya na akwara ozi.
Ọ bụ onye ọkà mmụta sayensị Japan bụ Shinya Yamanaka bu ụzọ tụpụta usoro a na 2006. Site na nnwale na ụmụ oke, ndị otu nyocha ya jiri vectors viral maka oge mbụ ịnyefe ngwakọta nke ihe odide ederede anọ (Oct3/4, Sox2, Klf4, na c-Myc). a na-akpọ "yamanaka factor") n'ime mkpụrụ ndụ somatic, na-emegharị ha ka ha nweta ụdị cell nke yiri sel sel embrayo, nke a makwaara dị ka induced pluripotent stem cell (iPSCs).
N'otu afọ ahụ, ndị na-eme nchọpụta na Stanford University School of Medicine chepụtara ụzọ ọhụrụ dị mma na nke dị nchebe nke nwere ike ime ka mkpụrụ ndụ sel nwere ike kpalite naanị site na iji protein ndị nwere mkpụrụ ndụ ihe nketa. Ihe nchoputa a kwuputara nke oma na uzo nje gara aga na ngbanwe di ala ma biputara ya na onu ogugu nke October 26.
Juan Carlos Izpisúa Belmonte, onye ọkà mmụta ihe ndị Spen mara maka nyocha ya banyere embrayo ngwakọ mmadụ na enwe, na Steve Horvath, onye German biostatistician nke mepụtara "elekere ndu ndụ" maka ịlele ịka nká mmadụ, ga-esonye na otu ahụ, MIT Technology Review kọrọ na September. Maka ịchọpụta na enwere ike idegharị mkpụrụ ndụ tozuru oke n'ime mkpụrụ ndụ arụ ọrụ, Shinya Yamanaka, onye sayensị Japan nke meriri Nrite Nobel nke 2012, ga-abụ onye isi oche na onye ndụmọdụ pro bono na bọọdụ ndụmọdụ sayensị Altos.
Tụkwasị na nke ahụ, Manuel Serrano, bụ onye na-arụ ọrụ na Institute of Biomedical Research na Barcelona, Spain, kwadoro MIT Technology Review na Altos kpọrọ ya ka ọ banye n'òtù Cambridge nke ụlọ ọrụ ahụ maka ụgwọ ọnwa ise ruo okpukpu iri karịa ego ọ na-enweta ugbu a. Dị ka Serrano si kwuo, isi ihe mgbaru ọsọ Altos abụghị ịkpata ego, kama ọ bụ ịghọta ọrụ cell.
Onye nyocha Harvard David Sinclair na-ahụ nkwa pụrụ iche na mpaghara a. Ụlọ nyocha ya na-elekwasị anya ma usoro nhazigharị cell nwere ike ime ka akụkụ ahụ na anụ ahụ dị ọhụrụ. Disemba gara aga, o weghachiri ọhụụ ụmụ oke ahụ site na iji nhazigharị cell. "Ndị na-achụ ego etinyela ego buru ibu n'ihe gbasara nhazigharị cell, na ebumnuche bụ isi nke ime ka akụkụ ahụ ma ọ bụ akụkụ ahụ dum na-emegharị ahụ," ka o kwuru. ".
Alejandro Ocampo, onye prọfesọ na Mahadum Lausanne dị na Switzerland, kwenyere na a gaghị atụgharị teknụzụ a ka ọ bụrụ ọgwụ n'oge na-adịghị anya. "Echiche ahụ dị mma, mana enwere nnukwu hype, ọ dị anya na a ga-agbanwe ya, ọnụ ahịa ya dịkwa elu." "Nkà na ụzụ nhazigharị ka dị anya site na ọgwụgwọ mmadụ," ka o kwuru. Otu nsogbu bụ na nhazigharị ọ bụghị naanị na-eme ka mkpụrụ ndụ dị obere, kamakwa na-agbanwe ihe onwunwe ha - dịka ọmụmaatụ, ịtụgharị mkpụrụ ndụ akpụkpọ anụ ka ọ bụrụ sel steepụ. Ọ bụ ya mere teknụzụ a ji dị oke egwu ịnwale ndị mmadụ. ".
Buffett na Li Ka-shing chọsiri ike itinye ego na ọgwụ ogologo ndụ dabere na ngwaahịa NMN n'afọ ndị na-adịbeghị anya. N'afọ 2017, Li Ka-shing tinyere aka na NmN's upstream raw material sopplier, The American Company, iji mepụta ọgwụ mgbochi ịka nká. N'afọ 2019, ụlọ ọrụ na-ahụ maka ndị na-ebunye ndị ahịa Buffett MacLane kwupụtara mmekorita ya na herbal, ụlọ ọrụ America, iji wepụta ume ọhụrụ, "ọgwụ na-enweghị afọ."
Ụfọdụ ndị kwenyere na nke a bụ n'ihi na e nwere protein pụrụ iche n'ime ọbara, nke a na-akpọ uto dị iche iche nke 11 (protein differentiation factor 11), nke a na-akpọ GDF11, nke nwere ike ịrụzi ịka nká na akwara ọkpụkpụ mebiri emebi, na-akwalite mgbake ụbụrụ ụbụrụ na akwara ozi, ma laghachi azụ. mbelata ọgụgụ isi metụtara afọ.
Enwekwara echiche na ihe a niile metụtara ihe akpọrọ TIMP2. Aha zuru oke maka TIMP2 bụ anụ ahụ na-egbochi metalloproteinases 2. A na-ahụ ya n'ọtụtụ buru ibu n'ọbara ụdọ mmadụ, mana ọ na-agbada ngwa ngwa ka afọ. Ọ nwere ike melite plasticity na ọrụ nke neurons na hippocampus, nke bụ akụkụ nke ụbụrụ maka mmụta na ebe nchekwa.
Nke a bụ ihe ndabere: oge ọ bụla cell kewara, otu DNA nke dị na njedebe nke chromosome, ya bụ, telomeres, ga-aka nká, mgbe telomere nke cell na-eyicha kpamkpam, cell ahụ ga-abanye steeti ịka nká. Ọ bụrụ na anyị nwere ike igbu oge uwe telomere, ọ pụtara na anyị nwere ike ịdị ndụ ntakịrị.
Na onye nkuzi Sinclair anyị, ọ bụ ya bụ onye mbụ chọtara ụzọ iji gbakwunye NAD +. Ọ chọtara ihe a na-akpọ β-nicotinamide mononucleotide, nke anyị kpọtụrụ aha dị ka NmN (Nicotinamide mononucleotide). NMN bụ otu n'ime ihe mmalite nke NAD synthetic na ahụ mmadụ, nke nwere ike ịbawanye ọkwa NAD + na ahụ mmadụ.
Mahadum Washington mere ọmụmụ ihe ogologo oge - na-atụnyere NMN ọnụ ọnụ na ụmụ oke ịka nká nkịtị maka ọnwa 12, wee chọpụta na otu ọnụ ọnụ nwere ike wepụ ihe dị iche iche physiological n'ụzọ dị irè metụtara ịka nká, dị ka ibu ibu, nkwụsị nke metabolic, enweghị ike anụ ahụ. , Ọhụhụhụhụhụhụhụhụhụhụhụhụhụhụgane,makasịrina,izizikazinikọziziziziozizizikwaruozizizikwaruozizi ihe ndi ozo.
Na mbụ, naanị anyị nwere ike yigharịrị usoro glaucoma, mana ọ nweghị ụzọ isi gbanwee nhụsianya ahụ. Nnyocha Sinclair na-eme ka ndị mmadụ yie ka ha na-ahụ n'ezie ohere nke ịtụgharị ịka nká. Nke mere na mgbe Nature kọrọ banyere ọmụmụ ihe ahụ, ọ na-eji okwu ndị a bụ "Turning Back Time" na isiokwu mkpuchi nke mbipụta dị ugbu a.
Njikọ otu ya dịkwa oke ọnụ: dị ka Dr. Shinya Yamanaka, onye sụrụ ụzọ nhazigharị cell ma bụrụ onye mmeri nke 2012 Nobel Prize in Physiology or Medicine, na Dr. Izpisua Belmonte, bụ onye sụrụ ụzọ nyocha mgbanwe cell. N'afọ 2016, otu n'ime nnwale teknụzụ stem cell embrayo ya mere ka ụmụ oke nwee ike igosi akara mgbanwe afọ.
Akwụkwọ akụkọ bụ "Nature Metabolism" wepụtara nsonaazụ nyocha, ndị otu nyocha China weputara PCC1 (proanthocyanidin C1) site na mkpụrụ osisi vine akọwapụtara, PCC1 nwere ike wepu mkpụrụ ndụ nke ọma na n'enweghị nsogbu, ma jiri PCC1 naanị ya na ụmụ oke ndị na-eme ihe iji nyere ha aka ịgbatị ndụ etiti ahụike ha. site na 64.2%. Emere nyocha a site n'aka otu ndị ọkachamara sitere na Institutelọ Ọrụ Nri na Ahụ Ike nke Shanghai nke Mahadum Sayensị nke China, Tomson By-Health Institute, Buck Institute of Aging, Mayo Clinic na ụlọ ọrụ ọkachamara ndị ọzọ.
Akwụkwọ akụkọ bụ "Nature Metabolism" wepụtara nsonaazụ nyocha, ndị otu nyocha China weputara PCC1 (proanthocyanidin C1) site na mkpụrụ osisi vine akọwapụtara, PCC1 nwere ike wepu mkpụrụ ndụ nke ọma na n'enweghị nsogbu, ma jiri PCC1 naanị ya na ụmụ oke ndị na-eme ihe iji nyere ha aka ịgbatị ndụ etiti ahụike ha. site na 64.2%. Emere nyocha a site n'aka otu ndị ọkachamara sitere na Institutelọ Ọrụ Nri na Ahụ Ike nke Shanghai nke Mahadum Sayensị nke China, Tomson By-Health Institute, Buck Institute of Aging, Mayo Clinic na ụlọ ọrụ ọkachamara ndị ọzọ.
Na December 7, Nature Metabolism, akwụkwọ akụkọ sayensị kachasị elu nke ụwa, wepụtara nsonaazụ nyocha bụ isi "Flavonoid procyanidin C1 nwere ọrụ senotherapeutic ma na-abawanye ndụ n'ime ụmụ oke" - ndị otu nyocha China weputara PCC1 (proanthocyanidin C1) site na mkpụrụ osisi vine akọwapụtara. PCC1 nwere ike ịwepụ nke ọma ma wepụ mkpụrụ ndụ senescent n'enweghị nsogbu, na naanị PCC1 ka e ji mee ihe na ụmụ oke ndị na-eto eto iji nyere ha aka ịgbatị ogologo ndụ etiti ahụike ha site na 64.2%.
Emere nyocha a site n'aka otu ndị ọkachamara sitere na Institutelọ Ọrụ Nri na Ahụ Ike nke Shanghai nke Mahadum Sayensị nke China, Tomson By-Health Institute, Buck Institute of Aging, Mayo Clinic na ụlọ ọrụ ọkachamara ndị ọzọ. Zhang Xuguang, onye isi ụlọ ọrụ Tomson By-Health Technology Centre na-etinye aka na ọrụ a, kwuru na ndị otu ahụ nyochara ihe fọrọ nke nta ka ọ bụrụ otu puku ngwaahịa sitere n'okike, kpochie ya na ihe ọkụkụ 45 sitere na osisi gụnyere ụdị mkpụrụ osisi grape dị iche iche, ma mesịa chọta ihe nwere ike. "wepụ nke ọma mkpụrụ ndụ senescent" site na mkpụrụ vine akọwapụtara, PCC1.
N'ileghachi anya azụ na nchoputa nke PCC1, na mbido 2019, otu ndị ọkà mmụta sayensị na United States bipụtara na nke mbụ ya na akwụkwọ akụkọ "EbioMedicine" na "dasatinib + quercetin na ọgwụgwọ ọrịa na-egbu egbu metụtara ụmụ mmadụ", nke. mere ka ndị mmadụ mara nke a mgbochi ịka nká "kpakpando ejima nchikota" ma nye ọhụrụ oru nkwado maka mmepe nke mgbochi ịka nká ngwaahịa. Dasatinib, quercetin, na esceltenin bụ nke Senolytics, nke sụgharịrị n'ụzọ nkịtị dị ka "na-ebibi ịka nká", ma bụrụ nnukwu ọgwụ na-ewepụ mkpụrụ ndụ senescent site na itinye aka na SCs (senescent cell) ụzọ akara na nwa oge "na-akwụsịtụ" ụzọ mgbochi apoptotic. . Otú ọ dị, mmetụta ndị dị na Senolytics ekwesịghị ileda anya: anaemia, platelet na neutropenia. Ọ bụ ezie na nchịkwa oge na-adịghị anya nwere ike izere mmetụta ndị a, njedebe dị oke na ọnụnọ nke cytotoxicity na-ejedebe ngwa bara uru nke ọtụtụ Senolytics taa.
Ịchọta Senolytics nwere mmetụta dị ole na ole yana ike mkpochapụ ezubere iche bụ ebumnuche nkịtị nke ngalaba nyocha ịka nká zuru ụwa ọnụ na-achụ. Ndị otu nyocha nke China na-ahọrọ mịpụta mkpụrụ vine nwere ike kachasị na "ichebe mwepụ nke mkpụrụ ndụ senescent" maka nyocha miri emi karị, wee wepụta proanthocyanidin C1 nke ọma, ma ọ bụ PCC1 (Procyanidin C1). E jiri ya tụnyere ejima ejima, PCC1 nwere ike họrọ, rụọ ọrụ nke ọma na n'enweghị nsogbu wepụ mkpụrụ ndụ senescent na-enweghị ndabere ụdị cell, nsi dị elu na sel ndị na-abụghị nke anụ ahụ, yana obere arụmọrụ nke mkpochapụ cell senescent.
Na mgbakwunye na ịchọta ike PCC1 iji nwalee mgbochi ịka nká na ikpochapụ mkpụrụ ndụ senescent, ndị otu nyocha ahụ chọpụtakwara ọzọ n'ime ikike ya: ma ọ bụ gbochie mmepe tumor. Ndị nchọpụta ahụ chọpụtara na ịgbanye PCC1 n'ime ụmụ oke ụdị ọrịa tumor naanị na-emeghachi omume na mkpụrụ ndụ tumo. Ma mgbe PCC1 "na-arụkọ ọrụ ọnụ" na chemotherapy, ọnwụ nke chemotherapy na etuto ahụ na-abawanye nke ukwuu. A kwalitere ike iji PCC1 chemotherapy, yana 48.1% gbatịkwara oge ndụ nke ụmụ oke ihe atụ n'oge ntinye aka, nke dị ịtụnanya.
Na njedebe, ọ nwekwara ike ịbụ n'ihi na PCc1 "na-ehichapụ" mkpụrụ ndụ ịka nká nke microenvironment tumor, nke na-ebelata "enyemaka" nke mkpụrụ ndụ ndị agadi na ụbụrụ. Na njedebe, ike PCC1 ikpochapụ sel ndị agadi nọ na-egwu egwu, na enzymes imeju, ịdị arọ ahụ, urea na mgbochi nke ụmụ oke adịghị emetụta n'oge usoro ahụ dum, ya bụ, ọ dịghị mmetụta ọ bụla a chọtara.
Enwere ike ịhụ na nchoputa nke PCC1 nwere ike bụrụ ihe amali elu. Ọbụghị naanị na ogologo ndụ ndụ nke oke ahụike siri ike gbatịpụrụ site na 64.2% n'oge ntinye aka, nke bụ nnukwu ihe nhụsianya sitere n'okike; na enweghị mmetụta ọ bụla a hụrụ na usoro ahụ, nke dịkwa ụkọ n'etiti ihe ndị yiri ya. A na-atụ anya na a ga-eji nsonaazụ nyocha ahụ gbuo oge ịka nká na ịchịkwa ọrịa ndị metụtara ịka nká n'ọdịnihu, na a na-akpọkwa ya "ihe ọhụrụ dị ịrịba ama na ọgụ megide ịka nká" site na ụlọ ọrụ. Sun Yu, onye ọkachamara kachasị elu na otu nyocha ahụ, kwusiri ike na nchọpụta nke PCC1, na-akara oge mbụ na ngalaba mgbochi ịka nká nke China ewerewo ikike ikwu okwu banyere usoro mkpochapụ nke mkpụrụ ndụ senescent n'aka ya.
https://www.google.com/finance/quote/SYRS:NASDAQ?sa=X&ved=2ahUKEwjOz4Wj59D0AhVReXAKHfH7BN8Q3ecFegQICRAc.
Mpaghara nchịkwa nke genome na-achịkwa ngosipụta nke mkpụrụ ndụ ihe nketa, ịgbanwuo, gbanyụọ, na-ebili ma ọ bụ daa, dị ka mgba ọkụ na-ebelata, na-achọpụta omume nke mkpụrụ ndụ. N'ihi na okwu mkpụrụ ndụ ihe nketa bụ ihe ndabere nke ọrụ ekwentị niile, mgbanwe na mpaghara nchịkwa ndị a na-ebute n'ezie ọrịa niile. Otú ọ dị, ruo n'oge na-adịbeghị anya, ndị ọkà mmụta sayensị enweghị ngwá ọrụ iji mụọ mpaghara ndị a na-achịkwa, na-ahapụ ha ka a na-ejighị ya maka nchọpụta na mmepe ọgwụ.
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Map ebe mgbakọ na ụlọ oriri na ọṅụṅụ gburugburu
Weihai - Weihai International ngosi Center, China Weihai - Weihai International ngosi Center, China
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